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Updated: Jan 8, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

Published on: June 16, 2023

Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.

Manzoor Ahmad¹, Ríona M Devereux¹, Angela J Russell^1,2

¹Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

Angewandte Chemie (International Ed. in English)

|December 13, 2025

Summary

This summary is machine-generated.

Researchers developed novel near-infrared (NIR) light-activated anionophores for targeted cancer therapy. These photo-responsive molecules enable controlled ion transport, offering a promising alternative to current photodynamic therapies.

Keywords:

Anion transport Anions Hydrogen bonding Membranes Stimuli‐responsive

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Published on: August 30, 2017

Area of Science:

Supramolecular Chemistry
Chemical Biology
Nanomedicine

Background:

Artificial transmembrane anion carriers show promise in medicine, particularly as anticancer agents.
Stimuli-responsive systems offer targeted activation, but photo-activated ionophores often suffer from poor tissue penetration and cytotoxicity due to UV light triggers.
Near-infrared (NIR) light offers advantages for spatiotemporal control and remote activation in biological systems.

Purpose of the Study:

To develop novel photo-responsive anionophores activated by NIR light for targeted biological applications.
To investigate the mechanism of NIR-triggered anion transport using dynamic hydrogen bonding.
To evaluate the potential of these NIR-activated anionophores as a therapeutic strategy against cancer.

Main Methods:

Design and synthesis of BODIPY-caged photo-responsive anionophores utilizing a 4-hydroxyisophthalamide motif.
Investigation of NIR light-induced decaging and subsequent anion binding and transport.
Anion transport experiments in vesicles and cell-based assays to assess efficacy and cytotoxicity.

Main Results:

BODIPY-caged anionophores were successfully synthesized and demonstrated NIR light-triggered activation (730 nm).
Efficient off-on activation profiles for anion transport were observed in vesicle experiments.
NIR decaging induced turn-on transmembrane chloride transport in cancer cells, leading to a dose-dependent decrease in cell viability.

Conclusions:

NIR-activated photo-responsive anionophores offer a viable strategy for spatiotemporal control of ion transport.
These novel anionophores show significant potential as an alternative to existing photodynamic therapies for cancer treatment.
The developed system demonstrates effective cancer cell killing via controlled chloride transport upon NIR irradiation.