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Updated: Jan 8, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Yi Jin Jing Exercise Program Improves in Cognition, Sleep and Functional Mobility for Mild and Moderate Parkinson 's
1Department of Basic Education, Beijing Institute of Graphic Communication, Beijing, China.
Background:
Parkinson's disease (PD) is a neurodegenerative disorder of the basal ganglia that affects approximately 1.5% of adults over the age of 65. Exercise and physical activity are known to complement dopamine replacement therapy.
Methods:
A total of 90(68.4 ± 9.72 years) patients with mild and moderate PD participated in a randomized cross-over study. This trial tested that YI JING JING(YJJ) training of 6 months is superior to the control group (CG) at improving the cognition, sleep quality and functional mobility in patients with mild and moderate PD.
Results:
Group × Time interaction Effect :A significant interaction UPDRS-part III (F = 11.452, p <.001, η2 = 0.119), DS(PDSS-2) (F = 14.672, p <.001,η2 = 0.147),PDSS-2 Total (F = 24.813, p <.001, η2 = 0.226), BBS (Balance) (F = 32.764, p <.001, η2 = 0.278), suggests that the exercise intervention (YJJG) led to differential changes compared to the control group across variables. Time effect: Significant changes occurred from pretest to posttest regardless of YJJG UPDRS-part III (F = 18.327, p <.001 η2 = 0.177), DS(PDSS-2) (F = 10.836, p = .002 η2 = 0.112), PDSS-2 Total (F = 36.152, p <.001 η2 = 0.298), BBS (Balance) (F = 42.865, p <.001 η2 = 0.335) reflecting general temporal improvements or declines. There were not significant differences(p > .0038, η2 <0.05) from pretest to posttest in these 13 variables of CG.
Conclusion:
This study showed the efficacy of implementing the YJJ exercise program for 6 months on the sleep quality, motor function and balance in patients with mild to moderate PD.
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