Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formation of polyhedral photonic clusters driven by interfacial energy control in confined assembly.

Journal of colloid and interface science·2026
Same author

Verification of the value of optimization of the medication-related clinical decision support system in China, a hospital-based study.

JAMIA open·2026
Same author

Programmable miRNA-guided RNA-toxin switch for selective elimination of cancer cells.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Phase-separated hierarchical porous PLLA/Gelatin scaffolds for stem cell-mediated bone regeneration.

Tissue & cell·2026
Same author

Nanoscale exchange-bias magnetic tunnel junctions enabled memristive synapse and leaky-integrate-fire neuron for neuromorphic computing.

Nature communications·2026
Same author

Optimization Strategies of Polymeric Hydrogels and Decellularized Extracellular Matrices for Diabetic Chronic Wound Healing.

Biotechnology journal·2026

Related Experiment Video

Updated: Jan 8, 2026

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
07:47

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Published on: September 26, 2020

7.1K

A 3D Bioprinted PDA/CSCA/PAM Hybrid Hydrogel Patch for Myocardial Infarction Healing.

Yiran Tang1, Jie Xu1, Wang Liu1

  • 1Cancer Hospital of Dalian University of Technology, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China.

Biotechnology Journal
|December 13, 2025
PubMed
Summary

This study developed a novel conductive hydrogel cardiac patch from decellularized porcine tissue. The patch shows excellent mechanical properties, strong adhesion, and significant antimicrobial activity for myocardial infarction repair.

Keywords:
3D bioprintingL929 cellsPDA/CSCA/PAMdecellularized matrixtissue‐engineered myocardial patch

More Related Videos

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

9.2K
Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
04:40

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

Published on: July 2, 2017

10.7K

Related Experiment Videos

Last Updated: Jan 8, 2026

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
07:47

Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Published on: September 26, 2020

7.1K
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

9.2K
Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting
04:40

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

Published on: July 2, 2017

10.7K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Surgery

Background:

  • Cardiovascular diseases are a major cause of death globally.
  • Cardiac patches offer a promising surgical treatment for heart conditions.
  • Developing biocompatible and effective cardiac patches is crucial for myocardial repair.

Purpose of the Study:

  • To create a novel conductive hydrogel cardiac patch using decellularized porcine myocardial tissue.
  • To evaluate the mechanical properties, adhesion, antimicrobial activity, and biocompatibility of the developed patch.
  • To assess the potential of this patch for myocardial infarction repair.

Main Methods:

  • Porcine myocardial tissue was decellularized using SDS, Triton X-100, and DNase to obtain decellularized extracellular matrix (dECM).
  • A conductive hydrogel patch (PDA/CSCA/PAM) was fabricated with a porous structure.
  • The patch's mechanical properties, adhesion to various surfaces, bacterial inhibition, swelling ratio, hydrophilicity, hemolysis rate, and conductivity were quantitatively analyzed. Biosafety was assessed via ISO 10993-5 standards.

Main Results:

  • The dECM retained key components like collagen and GAGs.
  • The PDA/CSCA/PAM patch exhibited excellent adhesive strength on glass, stainless steel, and myocardial tissue.
  • The patch demonstrated significant antimicrobial efficacy and met critical tissue engineering standards, including conductivity and biocompatibility, with a hemolysis rate below 5%.

Conclusions:

  • The developed conductive hydrogel cardiac patch possesses superior mechanical compatibility, robust antimicrobial activity, and excellent biocompatibility.
  • This multifunctional patch shows high potential for clinical translation in repairing myocardial infarction.
  • The study highlights a promising biomaterial for advanced cardiovascular tissue engineering applications.