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Imprinting

Imprinting

Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

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Updated: Jun 30, 2026

Polymer Microarrays for High Throughput Discovery of Biomaterials

Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

Molecular Imprinting-Based Thickness-Encoded Suspension Arrays.

Ziling Ye¹, Junjie Zheng¹, Zhijie Pan¹

¹School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou 350000, China.

|December 13, 2025

Summary

This summary is machine-generated.

We developed a novel thickness-encoded microchip array for multiplexed detection, offering 440 distinct codes. This high-throughput platform provides sensitive biomarker detection for various diagnostic applications.

Keywords:

molecular imprinting multiplexed detection spectral-domain phase microscopy suspension array thickness encoded

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Area of Science:

Biomarker Discovery
Nanotechnology
Analytical Chemistry

Background:

Multiplexed simultaneous detection requires advanced encoding technologies with high capacity.
Existing methods often lack the necessary encoding capacity or are prohibitively expensive.

Purpose of the Study:

To present a novel suspension array platform for high-throughput, multiplexed detection.
To develop a thickness-encoded, MIP-functionalized quartz microchip array with a custom decoding system.

Main Methods:

Fabrication of MIP-functionalized quartz microchip arrays using a simple one-pot process.
Development of a custom thickness-fluorescence decoding system with micrometer-scale resolution.
Quantitative multiplexed assays for IgG detection.

Main Results:

Achieved 440 distinct codes with micrometer-scale resolution over a millimeter dynamic range.
Demonstrated detection limits of 7.6, 7.9, and 15 μg mL⁻¹ for human, mouse, and rabbit IgG.
Exhibited high sensitivity, selectivity, and temporal stability in quantitative multiplexed assays.

Conclusions:

The MIP-based thickness-encoded microchip array platform enables robust, high-throughput biomarker detection.
This cost-effective platform is suitable for environmental monitoring, food safety, and clinical diagnostics.