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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

897
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
897

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Related Experiment Video

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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Interhemispheric auditory tract microstructure in autism spectrum disorder: A diffusion tensor study.

Josie S Long1, Toshikazu Ikuta2

  • 1School of Medicine, Southern Illinois University, Carbondale IL, USA.

Psychiatry Research. Neuroimaging
|December 13, 2025
PubMed
Summary
This summary is machine-generated.

Autism spectrum disorder (ASD) is linked to differences in the brain's auditory pathway. This study found microstructural differences in the interhemispheric auditory tract in individuals with ASD.

Keywords:
Autism spectrum disorderDiffusion tensor imagingHypersensitivityInterhemispheric connectivityProbabilistic tractography

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Auditory Processing

Background:

  • Autism spectrum disorder (ASD) is characterized by social communication differences.
  • Individuals with ASD may also experience sensory or auditory-processing differences.
  • The interhemispheric auditory pathway's role in ASD is not well understood.

Purpose of the Study:

  • To investigate microstructural differences in the interhemispheric auditory pathway in individuals with ASD.
  • To explore the potential of this pathway as a biomarker for ASD.

Main Methods:

  • Diffusion tensor imaging data from the ABIDE dataset were analyzed.
  • Probabilistic tractography was used to reconstruct the interhemispheric auditory tract.
  • Diffusion metrics were compared between individuals with ASD and matched controls.

Main Results:

  • Analysis included data from 48 individuals with ASD and 38 controls.
  • The ASD group exhibited lower fractional anisotropy and higher radial diffusivity in the tract.
  • These findings suggest reduced microstructural coherence and potential myelin-related differences in the interhemispheric auditory pathway in ASD.

Conclusions:

  • Interhemispheric auditory connectivity appears to differ in individuals with ASD.
  • These differences may contribute to speech perception and communication challenges in ASD.
  • The interhemispheric auditory tract shows potential as a psychiatry-facing biomarker.