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3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
Published on: September 19, 2025
947
Thinking outside the (ventilator) box: Enteral ventilation in humans
Heather L Clark1, Kevin W Gibbs2
1Department of Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Med (New York, N.Y.)
|December 13, 2025
Summary
This study explored intrarectal perfluorodecalin as a novel enteral ventilation method. A single dose proved safe and well-tolerated in healthy men, suggesting potential for future clinical applications.
Area of Science:
- Medical research
- Gastroenterology
- Critical care medicine
Background:
- Enteral ventilation is an emerging concept for respiratory support.
- Perfluorodecalin, a liquid oxygen carrier, is being investigated for novel delivery methods.
- The safety and feasibility of intrarectal administration require thorough evaluation.
Purpose of the Study:
- To assess the safety and feasibility of intrarectal perfluorodecalin administration.
- To evaluate the tolerability of a single dose in human subjects.
- To determine the potential of this method for future therapeutic applications.
Main Methods:
- First-in-human clinical trial.
- Inclusion of healthy male participants.
- Administration of a single dose of intrarectal perfluorodecalin.
Main Results:
- The intrarectal administration of perfluorodecalin was found to be safe.
- The compound was well-tolerated by all participants.
- No significant adverse effects were reported during the trial.
Conclusions:
- A single dose of intrarectal perfluorodecalin is safe and feasible in healthy men.
- Further research is necessary to establish its efficacy in improving oxygenation in critically ill patients.
- This novel approach warrants continued investigation for respiratory support.
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