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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

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Published on: September 12, 2025

Three practice updates in non-Hodgkin lymphoma for 2026.

Rebecca L King¹, Sarah J Ondrejka², James R Cook²

¹Division of Hematopathology, Mayo Clinic, Rochester, MN, USA.

Human Pathology

|December 13, 2025

Summary

Navigating lymphoid neoplasms requires distinguishing between various non-Hodgkin lymphomas using morphology and ancillary studies. This review updates classifications for follicular lymphoma, high-grade B-cell lymphomas, and nodal T-cell lymphomas.

Keywords:

Follicular lymphoma High grade B-Cell lymphoma International consensus classification Non-Hodgkin lymphoma T-cell lymphoma

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Area of Science:

Hematology
Pathology
Oncology

Background:

Lymphoid neoplasms pose diagnostic challenges in surgical pathology.
Distinguishing non-Hodgkin lymphoma subtypes requires morphology and ancillary studies.
Current practice uses both the World Health Organization (5th ed.) and International Consensus Classification systems.

Purpose of the Study:

Provide practical updates on classifying challenging lymphoid neoplasms.
Offer guidance on follicular lymphoma, high-grade B-cell lymphomas, and nodal T-cell lymphomas.
Advise on ancillary studies and navigating current classification systems.

Main Methods:

Review of current literature and classification systems.
Focus on morphologic evaluation and ancillary studies (immunohistochemistry, flow cytometry, NGS).
Comparative analysis of classification approaches for specific lymphoma types.

Main Results:

Detailed evaluation strategies for follicular lymphoma subtypes.
Current approaches to high-grade B-cell lymphomas, including double-hit and NOS variants.
Features of common nodal T-cell lymphomas (T-follicular helper, anaplastic large cell, PTCL-NOS).

Conclusions:

Accurate classification of lymphoid neoplasms is crucial for patient management.
Understanding differences between classification systems aids diagnostic accuracy.
Ancillary studies are essential for definitive diagnosis and subtyping.