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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Related Experiment Video

Updated: Jan 8, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
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CTA-Based Carotid Plaque Reporting and Data System Classification Improves Risk Stratification for Ischemic

Limei Deng1, Weixiong Zeng1, Jingjing Yang1

  • 1From the Department of Diagnostic Imaging (L.D., W. Zeng, J.Y., Z.H., Y.L., G.Q., W.C.), Nanfang Hospital, Southern Medical University, Guangzhou, China.

AJNR. American Journal of Neuroradiology
|December 13, 2025
PubMed
Summary

Carotid Plaque-RADS on CTA improves risk assessment for ischemic cerebrovascular events (ICE) beyond stenosis severity alone. This system aids in identifying high-risk plaques, especially in mild to moderate stenosis, guiding earlier intervention for better outcomes.

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Area of Science:

  • Vascular imaging and neurology.
  • Radiology and cardiovascular disease research.

Background:

  • Ischemic cerebrovascular events (ICE) are a major cause of death and disability.
  • Carotid Plaque-RADS standardizes plaque assessment, but its prognostic value via CTA needs further exploration.

Purpose of the Study:

  • To evaluate the prognostic value of CTA-based Carotid Plaque-RADS for predicting ICE.
  • To compare the performance of Carotid Plaque-RADS with carotid stenosis severity in risk stratification.

Main Methods:

  • Retrospective analysis of 1,232 patients who underwent neck CTA, with 371 matched pairs using propensity score matching (PSM).
  • Independent assessment of carotid plaques using CTA-based Carotid Plaque-RADS by two radiologists.
  • Follow-up of 742 patients for a mean of 42 months to assess stroke outcomes using logistic regression, ROC, and Cox models.

Main Results:

  • Plaque-RADS ≥3 was more frequent in symptomatic patients and correlated with ICE.
  • Plaque-RADS 4c (intraluminal thrombus) showed the strongest prediction for ischemic events (OR 17.87).
  • Carotid Plaque-RADS significantly improved risk model discrimination (AUC 0.680 vs. 0.609) and identified as an independent risk factor for disease-free survival (DFS) and recurrence-free survival (RFS).

Conclusions:

  • CTA-based Carotid Plaque-RADS provides superior risk stratification for ICE compared to stenosis severity alone.
  • The system is particularly valuable in patients with mild to moderate stenosis.
  • Carotid Plaque-RADS may assist in guiding earlier interventions for patients at high risk of cerebrovascular events.