Diffuse idiopathic skeletal hyperostosis in patients with prediabetes

Area of Science:

• Rheumatology
• Endocrinology
• Radiology

Background:

• Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition characterized by widespread calcification and ossification of ligaments and entheses.
• Prediabetes is a state of impaired glucose metabolism that increases the risk of type 2 diabetes and cardiovascular disease.

Purpose of the Study:

• To determine the prevalence of DISH among patients diagnosed with prediabetes.
• To explore potential associations between DISH and clinical characteristics in a prediabetic cohort.

Main Methods:

• A prospective evaluation of 166 prediabetic patients.
• Thoracic and lumbar radiography was performed on 67 patients with symptoms suggestive of DISH.
• DISH diagnosis followed Resnick and Niwayama criteria; demographic, clinical, and laboratory data were analyzed.

Main Results:

• DISH was diagnosed in 9 patients, representing 5.4% of the overall cohort and 13.4% of symptomatic patients.
• Patients with DISH were significantly older (p=0.004) and more frequently hypertensive (p=0.047) than those without DISH.
• Trends toward higher body mass index, fasting glucose, and smoking rates were observed in the DISH group, but did not reach statistical significance.

Conclusions:

• This study is the first to investigate the frequency of DISH in a prediabetic population.
• Findings suggest a potential association between DISH and prediabetic status.
• Further research is warranted to confirm the relationship between DISH and prediabetes.