Multichannel intraluminal impedance-pH monitoring for evaluation of gastroesophageal reflux mimics in infants with comorbidities
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Diagnosing gastroesophageal reflux (GER)-like symptoms in infants with comorbidities is challenging. Multichannel intraluminal impedance-pH (MII-pH) monitoring showed abnormal GER in fewer infants with non-esophageal symptoms compared to those with esophageal symptoms.
Area Of Science
- Pediatric Gastroenterology
- Neonatology
- Critical Care Medicine
Background
- Infants with comorbidities and critical illnesses often present with symptoms mimicking extra-esophageal reflux.
- Differentiating these symptoms from underlying conditions is clinically challenging.
- This study focuses on equivocal gastroesophageal reflux (GER)-like symptoms in high-risk infants.
Purpose Of The Study
- To evaluate the characteristics of equivocal GER-like symptoms in infants with comorbidities.
- To assess the utility of 24-hour esophageal multichannel intraluminal impedance-pH (MII-pH) monitoring in this population.
- To identify patterns of GER in infants with specific comorbidities.
Main Methods
- Retrospective study of 79 infants under 1 year of age undergoing 24-hour MII-pH monitoring.
- Abnormal results defined by reflux index >10%, total reflux episodes >100, and specific thresholds for acidic/non-acidic reflux.
- Analysis of comorbidities including prematurity, laryngomalacia, neurological impairment, and bronchopulmonary dysplasia.
Main Results
- 64.6% of infants required intensive care; 70% presented with extra-esophageal symptoms.
- Common comorbidities included prematurity (65.8%), laryngomalacia (46.5%), and neurological impairment (40.5%).
- Abnormal MII-pH results were found in 39.2% of subjects, significantly higher in infants with esophageal symptoms. Infants with neurological impairment had fewer weakly acidic reflux episodes, while those with laryngomalacia had more proximal reflux episodes.
Conclusions
- Abnormal 24-hour esophageal MII-pH monitoring rates were lower in infants with non-esophageal symptoms compared to those with esophageal symptoms.
- Proton-pump inhibitor use is not routinely recommended for non-esophageal symptoms in high-risk infants without confirmed GERD.
- MII-pH monitoring provides valuable insights into GER characteristics in infants with specific comorbidities.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...