Prognostic Factors for Pectus Carinatum Treated by Dynamic Compression System: PECTUSDYN Trial

Area of Science:

• Thoracic surgery
• Orthopedics
• Pediatric surgery

Background:

• Pectus carinatum (PC) is a chest wall deformity.
• Dynamic compression bracing (DCB) offers a non-surgical treatment option for PC.
• Identifying prognostic factors can optimize DCB treatment outcomes.

Purpose of the Study:

• To identify prognostic factors for successful pectus height reduction using DCB.
• To evaluate the effectiveness of DCB in treating pectus carinatum.
• To analyze the relationship between initial correction pressure and treatment outcomes.

Main Methods:

• Retrospective review of 297 patients treated with DCB for PC (2011-2020).
• Primary outcome: ≤50% reduction in pectus height (PH) at 6 months, measured by radiation-free imaging.
• Statistical models adjusted for treatment compliance were employed.

Main Results:

• A mean PH reduction of -35.8% was observed at 6 months in 114 patients with available data.
• 53.5% of patients achieved ≥50% PH reduction.
• Higher initial correction pressure (PIC ≥ 7.5 psi) was significantly associated with greater PH reduction (OR=2.53, P=.024).

Conclusions:

• Initial correction pressure (PIC) is a significant prognostic factor for pectus height reduction with DCB.
• These findings require validation in ongoing prospective studies.
• DCB demonstrates effectiveness in non-surgical PC correction.