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Updated: Jan 8, 2026

Extraction of Extracellular Vesicles from Whole Tissue
Published on: February 7, 2019
Tumoroid-derived extracellular vesicles for prognosis and therapeutics: A valuable tool in precision medicine
Vijay Murali Ravi Mythili1, ArulJothi Kandasamy Nagarajan1, Vasanth Kanth Loganathbabu Thasma1
1Integrative Genetics and Molecular Oncology Group, Department of Genetic Engineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, India.
Abstract:
Precision medicine has transformed healthcare by tailoring treatment plans to an individual's genetic profile, in contrast to standardized therapies. Patient-derived tumoroids facilitate cancer research, while extracellular vesicles (EVs) provide insights into disease states. EVs from tumoroids serve as diagnostic tools for cancer, reflecting gene mutations and enabling minimally invasive tracking of disease progression. Artificial Intelligence (AI) enhances precision medicine by analyzing extensive datasets derived from tumors and EVs, thereby advancing cancer detection and therapy. The tumor microenvironment (TME) plays a pivotal role in tumor development and is studied using patient-derived organoids (PDOs), which accurately recapitulate tissue function and support drug screening and personalized treatment strategies. Integrating precision medicine with AI-driven analysis of tumoroids and EVs holds the potential to improve patient outcomes and quality of life through personalized treatment approaches.
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