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Electrochemical MicroRNA biosensors for kidney Cancer: From biomarker discovery to point-of-care diagnostics

Sadegh Zarei1, Seyed Morteza Hosseiniara2, Solmaz Sadat Hosseini Zijoud3

  • 1Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 14, 2025
PubMed

Insights

Electrochemical biosensors offer a sensitive method for detecting microRNAs (miRNAs) in liquid biopsies for kidney cancer (ccRCC) early detection. These advanced tools show promise for non-invasive diagnostics and personalized treatment monitoring.

Area of Science:

  • Biomedical Engineering
  • Molecular Diagnostics
  • Oncology

Background:

  • Clear cell renal cell carcinoma (ccRCC) diagnosis is challenged by late detection and ineffective current methods.
  • MicroRNAs (miRNAs) are emerging as stable, disease-specific biomarkers in liquid biopsies for early cancer detection.
  • Electrochemical biosensors offer sensitive, rapid, and cost-effective detection of biomarkers.

Purpose of the Study:

  • To explore the potential of electrochemical biosensors for detecting kidney cancer biomarkers.
  • To highlight advances in miRNA detection technologies for non-invasive cancer diagnostics.
  • To assess the clinical feasibility of electrochemical miRNA biosensors for ccRCC management.

Main Methods:

  • Utilizing liquid biopsy for minimally invasive sample collection.
  • Employing microRNAs (miRNAs) as biomarkers for kidney cancer.
  • Developing and integrating electrochemical biosensors with nanomaterials, amplification methods, and CRISPR-Cas systems.
  • Creating prototype sensors for ccRCC-relevant miRNAs and multiplexed detection.

Main Results:

  • Electrochemical biosensors demonstrate high sensitivity and specificity for miRNA detection.
  • Integration of advanced technologies enhances sensor performance for early cancer detection.
  • Prototype sensors and smartphone-compatible platforms show potential for clinical translation.

Conclusions:

  • Electrochemical miRNA biosensors hold transformative potential for non-invasive ccRCC diagnostics and treatment monitoring.
  • These biosensors can contribute to personalized medicine and precision oncology.
  • Further innovation and clinical validation are crucial for widespread adoption in patient management.
Keywords:
Clear cell renal cell carcinomaElectrochemical biosensorKidney cancerLiquid biopsyPoint-of-care diagnosticsmicroRNA

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