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Improving perinatal outcomes: A review of landmark trials that have changed obstetric practice

Mary Marchese1, Victoria Adewale1, Dwight J Rouse1

  • 1Department of Obstetrics & Gynecology, Warren Alpert Medical School of Brown University, Providence RI, USA.

Seminars in Perinatology
|December 14, 2025
PubMed

Over the past few decades, multiple landmark studies investigating interventions for perinatal benefit have determined best practices for obstetricians worldwide. In this review, we will highlight trials that have demonstrated the effects of maternal intervention for perinatal benefit, including latency antibiotics, antenatal steroids, fetal neuroprotective measures, intrapartum group B streptococcus (GBS) prophylaxis, and delivery timing.

Keywords:
Clinical trialsObstetricsReview

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