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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Screening for Esophageal Cancer.
Eugene Phan1,2, Shinya Ohashi3,4, Amitjeet Phajneek Singh1
1Department of Gastroenterology and Hepatology, Lyell McEwin Hospital, Elizabeth Vale, South Australia, Australia.
Journal of Gastroenterology and Hepatology
|December 14, 2025
Summary
Early detection of esophageal cancer, including esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), is crucial for improving survival rates. This review explores current and emerging screening strategies, emphasizing technological advancements for better outcomes.
Area of Science:
- Gastroenterology and Oncology
- Medical Technology and Diagnostics
Background:
- Esophageal cancer presents a significant global health challenge with low survival rates, primarily due to late diagnosis.
- Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are distinct subtypes with differing epidemiology, necessitating region-specific screening approaches.
Purpose of the Study:
- To review current and emerging strategies for the early detection of ESCC and EAC.
- To highlight the impact of technological innovations on esophageal cancer screening and patient outcomes.
Main Methods:
- Review of current endoscopic screening protocols for ESCC and EAC.
- Exploration of novel non-endoscopic screening technologies, including biomarker assays and AI-assisted imaging.
- Assessment of advancements in diagnostic precision and treatment efficacy.
Main Results:
- Population-based endoscopic screening is effective for ESCC in high-incidence regions.
- Targeted screening for Barrett's esophagus (BE) is the primary approach for EAC in Western countries.
- Technological advancements are enhancing diagnostic capabilities and reshaping screening paradigms.
Conclusions:
- Region-specific screening strategies are essential for managing esophageal cancer subtypes.
- Technological innovations in endoscopy and non-endoscopic methods hold significant promise for improving early detection and global outcomes for esophageal cancer.
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