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Updated: Jan 8, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Risk Factors for Biochemical Pregnancy in Women With Recurrent Pregnancy Loss: A Retrospective Cohort Study
Huyan Huo1, Ning Hu1, Yanting Yang1
1The Second Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China.
Objective:
To identify determinants of biochemical pregnancy (BP) in women with recurrent pregnancy loss (RPL) and develop a predictive nomogram.
Methods:
This retrospective study included 621 RPL patients (207 with BP, 414 with clinical pregnancy) at Lanzhou University Second Hospital (2019-2022). Clinical data were compared between groups. Univariate and multivariate logistic regression identified BP predictors, and a nomogram was developed. Model performance was assessed via AUC and calibration curves.
Results:
≥ 3 prior losses, assisted reproductive technology (ART), positive antinuclear antibody (ANA), positive lupus anticoagulant (LA), and elevated fasting glucose were independent BP risk factors (OR > 1, p < 0.05), while positive blocking antibody was protective (OR = 0.468, p = 0.029). The nomogram showed an AUC of 0.671 (95% CI: 0.627-0.716), with a well-fitted calibration curve (Hosmer-Lemeshow χ2 = 8.426, p = 0.393).
Conclusion:
This study developed a nomogram model incorporating multiple influential factors, thereby providing a robust tool for the clinical assessment of BP risk in RPL patients. Furthermore, it delivers valuable scientific insights to inform subsequent diagnostic approaches, therapeutic strategies, and preventative measures.
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