Photothermal-Mediated Topological-Covalent Tissue Adhesives: Synchronizing Robust Integration with Electrically...

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Bioelectronics

Background:

• Achieving robust adhesion and electrical integration between hydrogels and tissues is crucial for tissue engineering and bioelectronics.
• Conventional bioadhesives often rely on surface interactions, limiting their effectiveness and integration capabilities.

Purpose of the Study:

• To develop a photothermal-mediated bioadhesion strategy for atraumatic tissue adhesion and seamless electrical integration.
• To engineer functionalized polyaniline derivatives as bridging polymers for enhanced tissue-hydrogel interaction.

Main Methods:

• Molecular engineering of functionalized polyaniline derivatives.
• Utilizing photothermal effects for controlled tissue penetration and covalent-topological interaction formation.
• Characterization of interfacial properties and electrical conductivity through in vitro and in vivo studies.

Main Results:

• The strategy achieved photothermally controlled tissue penetration, forming a 3D interlocking network via covalent-topological interactions.
• Significantly reduced interfacial impedance and enabled effective electrical integration across the tissue-hydrogel interface.
• Demonstrated dual capability for electrophysiological monitoring and electrocoupling therapy in myocardial infarction models.

Conclusions:

• The photothermal bioadhesion strategy provides a novel approach for robust tissue adhesion and electrical integration.
• This method offers a simple, universal paradigm for applications in bioelectronic and regenerative medicine.
• The developed conducting polymer system enhances interfacial electrical properties for advanced biomedical applications.