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Updated: Jan 8, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Health-Related Quality of Life in Patients Undergoing Surgery for Primary Hyperparathyroidism: Patient Reported
Lily N Trinh1,2, Okenwa C Okose1,3, Amr H Abdelhamid-Ahmed1
1Division of Thyroid and Parathyroid Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
Background:
Parathyroidectomy is typically curative for primary hyperparathyroidism (PHPT) and may lead to health-related quality of life (HRQL) improvements. We aim to evaluate general and disease-specific HRQL changes in patients undergoing surgery for PHPT from their perspective.
Methods:
Patients completed three patient-reported outcome measure (PROM) surveys before and after surgery: (1) Worry survey; (2) Voice Handicap Index-10 (VHI-10); and (3) Patient-Reported Outcome Measurement Information System Global-10 (PROMIS).
Results:
Forty-four patients were included with a median age of 65 years, with 39 females (89%) included. Thirty-two patients (73%) had a single adenoma, and 12 (27%) had multigland disease (parathyroid hyperplasia). Worry scores related to parathyroid cancer, parathyroid surgery, and parathyroid-related problems significantly improved post-operatively (p < 0.05). On PROMIS assessment, there were improved scores in the physical health domain, mental health domain, and general health following parathyroid surgery for PHPT (p < 0.05).
Conclusion:
Patients with PHPT demonstrated significant improvements in HRQL following surgery.
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