Related Experiment Video
Updated: Jan 8, 2026
10:31
Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
15.1K
Cell population data as predictive biomarkers for biologic therapy response in psoriasis
Ruizhen Liu1,2,3,4,5,6,7, Can Zuo7, Juan Zhao7
1The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Expert Opinion on Biological Therapy
|December 15, 2025
Summary
Complete blood count parameters can predict biologic therapy response in psoriasis patients. Certain cell volume variations at baseline and early changes correlate with treatment effectiveness over 48 weeks.
Area of Science:
- Hematology
- Dermatology
- Immunology
Background:
- Biologic agents have advanced psoriasis treatment.
- Significant patient response variability necessitates predictive biomarkers for therapeutic efficacy.
Purpose of the Study:
- To investigate the predictive value of complete blood count parameters (CPD) for biologic therapy response in psoriasis.
- To analyze associations between baseline CPD, disease severity, and inflammatory markers.
- To monitor early dynamic changes in CPD and their relation to treatment outcomes.
Main Methods:
- Prospective cohort study of 422 psoriasis patients and 150 healthy controls.
- Measurement of 16 CPD parameters using a hematology analyzer.
- Analysis of baseline CPD, disease severity, and inflammatory markers, with 48-week follow-up for treatment response.
Main Results:
- All CPD parameters were significantly elevated in psoriasis patients versus controls (p < 0.001).
- Baseline mean lymphocyte volume (MN-V-LY) negatively correlated with PASI improvement (ρ = -0.278 to -0.449, p < 0.001).
- Early reduction in monocyte volume heterogeneity (SD-V-MO) correlated with long-term efficacy (ρ = -0.355 to -0.546, p < 0.001).
Conclusions:
- CPD parameters are elevated in psoriasis patients.
- Baseline MN-V-LY and early SD-V-MO changes predict biologic therapy response.
- CPD offer potential as simple, standardized biomarkers for clinical application in psoriasis treatment.
Related Concept Videos
01:21EPS and iPS Cells in Disease Research
3.3K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.3K
01:12Analysis of Population Pharmacokinetic Data
653
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
653
01:24T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
01:22iPS Cell Differentiation
3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K