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Major Somatic Sensory Pathways01:28

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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Patterns of Structural Disconnection Driving Proprioceptive Deficits in Chronic Stroke.

Mika Kaeja1, Leyla Gajiyeva2, Yasser Iturria-Medina3

  • 1Neural Architecture, Behaviour and Connectivity Laboratory, Department of Psychology, Center for Studies in Behavioral Neurobiology and School of Health, Concordia University, Montreal, QC, Canada (M.K., C.J.S.).

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|December 15, 2025
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Summary
This summary is machine-generated.

Stroke survivors often experience proprioceptive impairments due to white matter disconnection. This study links these deficits to specific brain network damage, offering insights for targeted stroke rehabilitation.

Keywords:
connectomeneuroimagingproprioceptionroboticsstroke

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Area of Science:

  • Neuroscience
  • Neurology
  • Rehabilitation Medicine

Background:

  • Stroke is a primary cause of death and disability, with proprioceptive deficits affecting a significant portion of survivors.
  • These impairments impede sensorimotor recovery and reduce post-stroke quality of life.
  • Understanding the neural basis of proprioception is crucial for effective rehabilitation, yet clinical assessments are limited.

Purpose of the Study:

  • To investigate the relationship between white matter (WM) disconnection and proprioceptive deficits in chronic stroke survivors.
  • To identify specific WM disconnection patterns underlying proprioceptive impairments using connectome-based lesion-symptom mapping.
  • To differentiate proprioceptive deficits from motor impairments in stroke recovery.

Main Methods:

  • Utilized a single-center observational study design with chronic stroke survivors.
  • Employed quantitative proprioceptive measurements via an arm position matching task and kinematic assessments.
  • Applied connectome-based lesion-symptom mapping to analyze WM disconnection patterns in relation to proprioceptive scores, controlling for motor performance.

Main Results:

  • Significant associations were found between WM disconnection and proprioceptive deficits in multiple tracts crucial for proprioception.
  • These associations remained significant even after controlling for motor performance, isolating proprioceptive-specific effects.
  • The findings demonstrate a link between network-wide WM disconnection and impaired proprioception in chronic stroke.

Conclusions:

  • Proprioceptive impairments following stroke are likely caused by network-wide WM disconnection in critical mediating tracts.
  • Connectome-based lesion-symptom mapping is a valuable tool for assessing stroke-related proprioceptive deficits.
  • The study provides a framework for network-informed assessments to guide targeted post-stroke therapies.