Related Experiment Video
Updated: Jan 8, 2026
11:13
Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
2.2K
Multifaceted Role of Tiliroside in Inflammatory Pathways: Mechanisms and Prospects
Gurjeet Kaur1, Jasleen Kaur1, Jayant Goyal1
1Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
Recent Advances in Inflammation & Allergy Drug Discovery
|December 15, 2025
Summary
Tiliroside, a natural compound, effectively reduces inflammation by inhibiting key pathways and reducing oxidative stress. Its potential is promising for treating inflammatory diseases like arthritis and inflammatory bowel disease.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Immunology
Background:
- Tiliroside is a natural polyphenolic compound with recognized anti-inflammatory potential.
- Inflammation is implicated in numerous chronic diseases, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review the anti-inflammatory functions and therapeutic prospects of Tiliroside.
- To elucidate the mechanisms underlying Tiliroside's effects on inflammation-related diseases.
Main Methods:
- Literature review of preclinical studies on Tiliroside.
- Analysis of Tiliroside's impact on inflammatory mediators and signaling pathways.
- Evaluation of Tiliroside's antioxidant and immunomodulatory properties.
Main Results:
- Tiliroside inhibits inflammatory cytokines, chemokines, and the NF-κB pathway.
- It possesses significant antioxidant properties, mitigating oxidative stress.
- Preclinical studies show efficacy in rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis.
Conclusions:
- Tiliroside demonstrates multifaceted anti-inflammatory activity through various mechanisms.
- Its immunomodulatory and tissue-regenerative properties suggest potential as a multimodal therapeutic agent.
- Further understanding of Tiliroside's mechanisms may lead to novel treatments for inflammation-associated disorders.
More Related Videos
Related Concept Videos
01:24T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
01:28Inflammatory Response
15.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.8K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
445
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
445
01:29Inflammatory Bowel Disease IV: Pharmacological Management
445
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
445
01:20The JAK-STAT Signaling Pathway
11.8K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
11.8K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
459
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
459