Clinical study on postoperative inflammation and cardiac function improvement following valve replacement surgery

Area of Science:

• Cardiology
• Biomarkers
• Surgical Outcomes

Background:

• Post-valve replacement surgery, C-reactive protein (CRP) is a key inflammatory marker.
• Assessing early postoperative CRP levels may predict cardiac function recovery.
• Understanding risk factors is crucial for perioperative management.

Purpose of the Study:

• To investigate the impact of postoperative day 3 CRP levels on cardiac function recovery at 3 months after valve replacement.
• To analyze the association between CRP levels and clinical risk factors for recovery.
• To provide reference data for perioperative management strategies.

Main Methods:

• Retrospective analysis of 188 valve replacement surgery patients.
• Patients grouped by postoperative day 3 CRP levels (high vs. low inflammation).
• Comparison of clinical characteristics, inflammatory markers, cardiac function (LVEF, BNP), and outcomes; logistic regression analysis used.

Main Results:

• Higher CRP levels correlated with lower cardiac function improvement rates (71% vs. 85.2%) and longer hospital stays.
• Patients with high CRP showed lower LVEF and higher BNP levels at 1 week and 3 months postoperatively.
• Multivariate analysis identified advanced age and lower preoperative LVEF as independent risk factors for poor recovery.

Conclusions:

• Elevated CRP on postoperative day 3 significantly impairs cardiac function recovery and prolongs hospitalization.
• Advanced age and reduced preoperative LVEF are critical independent predictors of adverse cardiac recovery.
• Early CRP monitoring can inform perioperative management and risk stratification.