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Updated: Jan 8, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
The relationship between triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular high risk: a
Pengcheng Li1,2, Jirui Cai2, Shuaifang Yuan2
1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Aims:
The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio reflects the balance between atherogenic and anti-atherogenic lipid fractions. The study aims to investigate the utility of the TG/HDL-C ratio in identifying high-risk groups for cardiovascular disease (CVD) within the general population.
Methods:
The current study was a branch of the ChinaHEART cohort in middle China that involved a total of 6,593 community-dwelling adults. We examine the association between TG/HDL-C and CVD high-risk in a cross-sectional investigation.
Results:
Results from restricted cubic spline and ROC analyses revealed a significant relationship between higher TG/HDL-C levels and increased odds of CVD high-risk, with the ratio exhibiting good discriminatory power (AUC = 0.820 in the fully adjusted model). Logistic regression further supported this association, indicating a 1.21-fold rise in the odds of high risk for each unit increase in TG/HDL-C.
Conclusions:
The TG/HDL ratio shows promise for CVD risk assessment. Incorporating the TG/HDL ratio into risk assessment models may provide supplementary information to healthcare professionals for risk stratification.
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