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Updated: Jun 18, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
Assessment of biodentine, mineral trioxide aggregate and enamel matrix derivative as direct pulp-capping agents
Shivali Vaid1, Ankitha Ade2, Abhishek Mishra3
1Department of Oral Maxillofacial Pathology & Microbiology, MaharanaPratap College of Dentistry & Research Centre, Gwalior, Madhya Pradesh, India.
Abstract:
Conservative pulp treatments are used to maintain the tooth's vitality. Therefore, it is of interest to assess the clinical, radiographic and histologic responses of the pulp-dentin complex after direct capping with the MTA, Biodentine and Enamel Matrix Derivative (EMD) in human permanent teeth. A sterile rotary round bur was used to mechanically expose the pulps of 36 premolars that were advised for extraction. The teeth were then divided to one of three experimental groups: MTA, Biodentine and Enamel Matrix Derivative (EMD). The creation of the dentine bridge was evaluated using radiographs and histology. Clinically absence of signs symptoms was noted. MTA had the highest dentine bridge formation, followed by biodentine and EMD.
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