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Myocardial infarction and coronary artery stenosis- An autopsy study

Anil Kumar Nagar1, Noorulla K A S2, Peeyush Ranjan1

  • 1Department of Forensic Medicine and Toxicology, Bundelkhand medical College Sagar, Madhya Pradesh, India.

Bioinformation
|December 15, 2025
PubMed

Insights

Autopsy analysis of 17 hearts revealed significant associations between coronary artery stenosis, myocardial ischemia, and advancing age, predominantly in males. This highlights the impact of coronary artery disease progression.

Area of Science:

  • Cardiovascular Pathology
  • Forensic Medicine
  • Cardiac Anatomy

Background:

  • Coronary artery pathology, including plaque buildup and thrombus formation, is a critical factor in myocardial ischemia.
  • Evaluating coronary artery stenosis is essential for understanding ischemic heart disease.
  • Autopsy provides a direct method for examining cardiac structures and pathologies.

Purpose of the Study:

  • To investigate autopsy findings related to coronary artery pathology.
  • To identify the presence of occlusion (plaques or thrombus) and assess coronary artery stenosis.
  • To correlate these findings with myocardial ischemia and demographic factors.

Main Methods:

  • Analysis of 17 hearts exhibiting ischemic changes from a total of 110 autopsy cases.
  • Detailed examination of coronary artery pathology, including stenosis and occlusion.
  • Staining techniques to identify and map the location of myocardial infarcts in the left ventricle (LV).

Main Results:

  • Ischemic changes were observed in 17 hearts (15 males, 2 females).
  • Infarct locations in the LV included the anterior wall (8 cases), septal wall (4 cases), papillary muscle (5 cases), and lateral wall (2 cases).
  • A significant association was found between coronary artery stenosis, myocardial ischemia, and increasing age, with a higher prevalence in males.

Conclusions:

  • Coronary artery stenosis and subsequent myocardial ischemia are significantly associated with advancing age, particularly in males.
  • Autopsy findings confirm the link between coronary artery pathology and ischemic heart disease.
  • The study underscores the importance of considering age and sex in the context of coronary artery disease progression.

Keywords:
Bundelkhandcardiovascular diseasescoronary artery stenosis ischemiamyocardial infarction

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