Related Experiment Video
Updated: Jan 8, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
Published on: November 30, 2022
Biostatistical challenges in multicenter clinical trials: Best practices for collaboration and data harmonization
Deepankar Satapathy1, Madhavi Eerike2, Sanket Mishra3
1Department of Orthopaedics, AIIMS, Bibinagar, Hyderabad, India.
None:
Multicentre orthopaedic clinical trials present distinct biostatistical and operational challenges that can affect the reliability and generalizability of their findings. Differences in site protocols, patient demographics, outcome measurements and regulatory environments contribute to data variability and complexity. This review discusses key strategies to address these issues, including the implementation of multilevel statistical models, development of uniform data collection tools and centralized processes for outcome assessment. Emphasis is placed on the value of early, coordinated planning and sustained collaboration among participating centers to ensure consistency and quality across sites. The review also explores the potential of digital technologies to streamline data integration and support harmonized workflows. By promoting methodological rigor and cross-institutional cooperation, these approaches aim to enhance the validity and impact of orthopaedic multicentre trial outcomes.
Related Concept Videos
Statistical Software for Data Analysis and Clinical Trials
Biostatistics: Overview
Discrete variables are...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Overview of Biostatistics in Health Sciences
Clinical Trials
There are four phases in a clinical trial. A phase one...
Study Design in Statistics
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...

