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Association Between the Creatinine-to-Body Weight Ratio and All-Cause Mortality in a Rural Japanese Community.

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The creatinine-to-body weight (Cr/BW) ratio is a significant predictor of all-cause mortality risk. Maintaining an optimal Cr/BW ratio may help reduce overall mortality rates.

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Area of Science:

  • Gerontology
  • Epidemiology
  • Biomarkers

Background:

  • Limited evidence exists on the association between the creatinine-to-body weight (Cr/BW) ratio and all-cause mortality.
  • The Cr/BW ratio may serve as a novel prognostic indicator for mortality risk.

Purpose of the Study:

  • To investigate the association between baseline Cr/BW ratio and survival over 10- and 22-year follow-up periods.
  • To determine the predictive value of the Cr/BW ratio for all-cause mortality in a population-based cohort.

Main Methods:

  • Prospective, population-based cohort study with 3517 participants (1553 men, 1964 women).
  • Participants categorized into four groups based on baseline Cr/BW ratio.
  • Cox proportional hazards regression analysis adjusted for multiple covariates.

Main Results:

  • A significant positive association was found between Cr/BW ratio and all-cause mortality risk (HR, 1.73; 95% CI, 1.28-2.35).
  • Adjusted HRs for mortality increased with higher Cr/BW ratio categories compared to the lowest category.
  • The optimal cutoff value for Cr/BW ratio predicting all-cause mortality was 1.23.

Conclusions:

  • The Cr/BW ratio is a significant predictor of subsequent mortality.
  • Strategies focusing on maintaining an optimal Cr/BW ratio range may contribute to reducing overall mortality.