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Published on: December 16, 2022
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The interaction effect of physical activity and sleep on cognitive function in stroke
Ryan G Stein1,2,3,4, Ryan S Falck1,2,3,4, Daria Tai1,2,3
1Aging, Mobility, and Cognitive Health Laboratory The University of British Columbia Vancouver British Columbia Canada.
Alzheimer'S & Dementia (New York, N. Y.)
|December 15, 2025
Summary
Moderate to vigorous physical activity may improve cognitive function in stroke survivors with short sleep duration, especially in males. This highlights the potential of physical activity to counteract sleep
Area of Science:
- Neuroscience
- Gerontology
- Rehabilitation Medicine
Background:
- Stroke survivors face a doubled risk of dementia.
- Poor sleep and cognitive impairment are prevalent post-stroke.
- Physical activity is known to benefit cognitive function.
Purpose of the Study:
- To investigate the interaction between physical activity and sleep on cognitive function in chronic stroke survivors.
- To determine if physical activity can mitigate the negative effects of poor sleep on cognition.
Main Methods:
- Cross-sectional study of 97 community-dwelling adults (≥55 years) with chronic stroke.
- Objective measurement of physical activity (MVPA, light PA) and sleep (duration, quality) via accelerometry.
- Cognitive function assessed using ADAS-Cog-13, with sex-stratified interaction analyses.
Main Results:
- A significant interaction between moderate-to-vigorous physical activity (MVPA) and sleep duration on cognitive function (ADAS-Cog-13 score) was found in the full sample.
- Individuals with shorter sleep duration and higher MVPA demonstrated better cognitive performance.
- The interaction effect was significant in males but not in females.
Conclusions:
- Moderate-to-vigorous physical activity may offset the detrimental effects of insufficient sleep on cognitive function in stroke survivors.
- This mitigating effect appears particularly pronounced in males.
- Physical activity represents a potential strategy to support cognitive health in this population.
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