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Related Concept Videos

Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
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Related Experiment Video

Updated: Jan 8, 2026

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein
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Neuroprotective properties of extra virgin olive oil polyphenols in Alzheimer's disease: a multi-target mechanistic

Lin Wei1, Zhenmin Li2, Mingqin Shi3

  • 1School of Basic Medical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, China.

Frontiers in Nutrition
|December 15, 2025
PubMed
Summary

Extra virgin olive oil polyphenols offer a promising multi-target approach to combat Alzheimer's disease (AD) pathology. These compounds may delay AD progression by addressing key pathways like amyloid aggregation and neuroinflammation.

Keywords:
Alzheimer’s diseaseextra virgin olive oilmulti-targetneuroprotective effectspolyphenols

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Nutritional Science

Background:

  • Alzheimer's disease (AD) involves complex pathologies including amyloid-beta (Aβ) deposition, tau tangles, neuroinflammation, and mitochondrial dysfunction.
  • Single-target drugs show limited efficacy, driving interest in multi-target strategies.
  • Extra virgin olive oil (EVOO) polyphenols are recognized for their diverse bioactive properties.

Purpose of the Study:

  • To systematically review the neuroprotective mechanisms of key EVOO polyphenols against Alzheimer's disease (AD) pathology.
  • To highlight the potential of EVOO polyphenols as a multi-target therapeutic strategy for AD.

Main Methods:

  • Systematic review of preclinical studies (in vitro and in vivo) examining EVOO polyphenols.
  • Analysis of the molecular mechanisms of hydroxytyrosol, oleuropein, tyrosol, verbascoside, oleocanthal, and ligustroside in AD models.

Main Results:

  • EVOO polyphenols synergistically inhibit Aβ and tau aggregation.
  • These compounds mitigate neuroinflammation, oxidative stress, and mitochondrial dysfunction.
  • Preclinical studies demonstrate amelioration of cognitive deficits and AD hallmarks by EVOO polyphenols.

Conclusions:

  • EVOO polyphenols represent a promising multi-target therapeutic avenue for Alzheimer's disease.
  • Further research and clinical trials are needed to validate efficacy and develop optimized formulations for AD treatment.