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Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
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Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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Intestinal ZIP8 Regulates Tissue Manganese Distribution and Modifies Manganese Overload in ZIP14 Deficiency.

Yuze Wu1, Shannon McCabe1, Ningning Zhao1

  • 1School of Nutritional Sciences and Wellness, The University of Arizona, Tucson 85721, Arizona, USA.

Journal of Nutrition and Metabolism
|December 15, 2025
PubMed
Summary
This summary is machine-generated.

Intestinal ZIP8 (SLC39A8) influences manganese distribution in tissues. Its absence affects manganese levels, particularly in females with ZIP14 deficiency, impacting absorption and potentially overload.

Keywords:
ZIP14ZIP8manganesemetalnutrienttransport

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Area of Science:

  • Cell Biology
  • Nutritional Science
  • Genetics

Background:

  • ZIP8 (SLC39A8) is a metal transporter involved in manganese, zinc, and iron uptake.
  • Its specific function within the intestinal epithelium is not well understood.

Purpose of the Study:

  • To investigate the role of intestinal ZIP8 in manganese absorption and tissue distribution.
  • To examine the interaction between ZIP8 and ZIP14 in manganese homeostasis.

Main Methods:

  • Utilized intestine-specific Zip8 knockout (Zip8-I-KO) mice.
  • Created double knockout mice by crossing Zip8-I-KO with Zip14-/- mice.
  • Confirmed ZIP8 localization to the apical membrane of Caco-2 cells.

Main Results:

  • Intestinal ZIP8 deletion reduced manganese in the liver and bone but not blood under basal conditions.
  • In ZIP14-deficient mice, intestinal ZIP8 deletion significantly lowered blood and brain manganese in females, but not males.
  • Bone manganese remained elevated across all experimental groups.

Conclusions:

  • Intestinal ZIP8 plays a role in manganese absorption and tissue distribution.
  • The effect of intestinal ZIP8 on manganese levels is sex-dependent and can modify manganese overload in ZIP14 deficiency.