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Investigating Why Comparing Intravenous and Perineural Dexamethasone Is Scientifically Unfounded

Kartik Sonawane1

  • 1Anesthesiology, Ganga Medical Centre and Hospitals Pvt. Ltd., Coimbatore, IND.

Cureus
|December 15, 2025
PubMed
Summary

Intravenous (IV) and perineural dexamethasone are not interchangeable in regional anesthesia. This editorial argues for context-specific use based on distinct systemic versus local nerve benefits, optimizing patient outcomes.

Keywords:
block prolongationdexamethasoneerasintravenousneuroprotectionperineuralperineural adjuvantspharmacokineticsregional anesthesia

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