Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

179
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
179
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

133
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
133
Blind Procedures02:07

Blind Procedures

12.8K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
12.8K
Crossover Experiments01:16

Crossover Experiments

4.5K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.5K
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

162
Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
162
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

229
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
229

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioactive molecules from Agave salmiana bagasse: Study of their antioxidant, prebiotic potential, and cytotoxicity.

Food research international (Ottawa, Ont.)·2026
Same author

Evaluation of Agave salmiana by-products as a functional ingredient for the development of sustainable foods.

Journal of the science of food and agriculture·2025
Same author

Edible Mushrooms: a Nutrient-Rich Ingredient for Healthier Food Products - A Review.

Current nutrition reports·2025
Same author

Diagnosis and Treatment of Spondylodiscitis: Insights From a Five-Year Single-Center Study.

Cureus·2024
Same author

A postdoctoral training program in bioimage analysis.

Molecular biology of the cell·2024
Same author

A Postdoctoral Training Program in Bioimage Analysis.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Jan 8, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
10:02

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Published on: July 23, 2016

33.2K

Patient Perspectives on Handling Single-Dose versus Multi-Dose Eye Drops: A Cross-Over Study.

José António Dias1, João Filipe Silva2, Nuno Lopes3

  • 1Department of Ophthalmology, Joaquim Chaves Saúde, Lisbon, Portugal.

Clinical Ophthalmology (Auckland, N.Z.)
|December 15, 2025
PubMed
Summary
This summary is machine-generated.

Multi-dose eye drop containers offer superior usability and convenience over single-dose options. Patients preferred multi-dose containers for easier handling and application, indicating better overall patient experience with this format.

Keywords:
Eye dropscontainershandlingmulti-dosesingle-doseusability

More Related Videos

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.5K
Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways
05:26

Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways

Published on: April 12, 2024

2.4K

Related Experiment Videos

Last Updated: Jan 8, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
10:02

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Published on: July 23, 2016

33.2K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.5K
Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways
05:26

Author Spotlight: Exploring Press Needle Efficacy and Underlying Molecular Pathways

Published on: April 12, 2024

2.4K

Area of Science:

  • Ophthalmology
  • Patient Care
  • Pharmaceutical Packaging

Background:

  • Limited data exists on the comparative usability of single-dose versus multi-dose eye drop containers.
  • Patient-reported outcomes are crucial for evaluating ophthalmic medication delivery systems.

Purpose of the Study:

  • To evaluate and compare the usability, convenience, and patient preferences for single-dose and multi-dose eye drop containers.
  • To identify which eye drop container format offers a better patient experience.

Main Methods:

  • A prospective, open-label, multicenter, cross-over study was conducted with 114 participants aged 50 years and older.
  • Participants used both multi-dose and single-dose eye drop containers sequentially.
  • Usability, convenience, and patient preferences were assessed using a novel questionnaire.

Main Results:

  • Participants found multi-dose containers easier to open and use for eye drop application compared to single-dose containers.
  • Multi-dose containers showed less residual medication upon disposal and featured more legible labels.
  • Overall handling and application were rated as better for multi-dose containers.

Conclusions:

  • Multi-dose eye drop containers are associated with enhanced handling and usability compared to single-dose alternatives.
  • Findings suggest multi-dose containers may improve patient adherence and satisfaction in ophthalmic treatments.