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Patient Perspectives on Handling Single-Dose versus Multi-Dose Eye Drops: A Cross-Over Study
José António Dias1, João Filipe Silva2, Nuno Lopes3
1Department of Ophthalmology, Joaquim Chaves Saúde, Lisbon, Portugal.
Clinical Ophthalmology (Auckland, N.Z.)
|December 15, 2025
Summary
Multi-dose eye drop containers offer superior usability and convenience over single-dose options. Patients preferred multi-dose containers for easier handling and application, indicating better overall patient experience with this format.
Area of Science:
- Ophthalmology
- Patient Care
- Pharmaceutical Packaging
Background:
- Limited data exists on the comparative usability of single-dose versus multi-dose eye drop containers.
- Patient-reported outcomes are crucial for evaluating ophthalmic medication delivery systems.
Purpose of the Study:
- To evaluate and compare the usability, convenience, and patient preferences for single-dose and multi-dose eye drop containers.
- To identify which eye drop container format offers a better patient experience.
Main Methods:
- A prospective, open-label, multicenter, cross-over study was conducted with 114 participants aged 50 years and older.
- Participants used both multi-dose and single-dose eye drop containers sequentially.
- Usability, convenience, and patient preferences were assessed using a novel questionnaire.
Main Results:
- Participants found multi-dose containers easier to open and use for eye drop application compared to single-dose containers.
- Multi-dose containers showed less residual medication upon disposal and featured more legible labels.
- Overall handling and application were rated as better for multi-dose containers.
Conclusions:
- Multi-dose eye drop containers are associated with enhanced handling and usability compared to single-dose alternatives.
- Findings suggest multi-dose containers may improve patient adherence and satisfaction in ophthalmic treatments.
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