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Updated: Jan 8, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
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Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

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Graded Notch Signaling Functions as a Rheostat of Lineage Plasticity and Therapy Resistance in Prostate Cancer

Yuyin Jiang, Siyuan Cheng, Catherine Yijia Zhang

    Biorxiv : the Preprint Server for Biology
    |December 15, 2025
    PubMed
    Summary

    Notch signaling acts as a rheostat controlling prostate cancer cell fate. Its dynamic rewiring drives resistance to enzalutamide therapy by promoting progenitor cells, but inhibiting Notch restores treatment sensitivity.

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