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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures

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Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo

H L Tucker¹, B Karat², A T De Ruiter³

¹Diagnostic Radiology, Department of Clinical Sciences, Lund University, Lund, Sweden.

Biorxiv : the Preprint Server for Biology

|December 15, 2025

Summary

This study mapped human hippocampal subfield variability using postmortem MRI and histology. Findings refine segmentation protocols for in vivo MRI, crucial for understanding cognition and neurological disorders.

Keywords:

Hippocampal subfields in vivo MRI postmortem MRI segmentation subicular complex

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Area of Science:

Neuroimaging
Human Anatomy
Magnetic Resonance Imaging

Background:

High-resolution in vivo MRI of hippocampal subfields is vital for studying cognition and disease.
Current segmentation relies on limited postmortem data, hindering accurate variability assessment.

Purpose of the Study:

To characterize hippocampal subfield border variability using ultra-high-resolution postmortem MRI and histology.
To inform the development and harmonization of in vivo MRI segmentation protocols.

Main Methods:

Analyzed two ultra-high-resolution postmortem MRI datasets with histological annotations.
Examined subfield and subregional appearance/disappearance, border locations, and associations with clinical/demographic factors.

Main Results:

Confirmed consistent subfield and subregional (subiculum) ordering along the hippocampus.
Pre/parasubiculum occupied ~50% of the subicular complex in the hippocampal body.
Hippocampal head digitations were unreliable for CA3 localization; SRLM proportionality offered a potential alternative.

Conclusions:

Established consistent anatomical landmarks for hippocampal subfield segmentation.
Findings support improved interpretation of in vivo MRI studies for cognition and neurological disorders.
No significant associations found between anatomical variability and diagnosis or demographic factors.