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Alpha-lipoic acid ameliorates nab-paclitaxel-induced peripheral neuropathy by inhibiting IL-17 signaling pathway
Hong Sun1, Yuxin Cai2, Ling Li1
1Department of Pharmacy, Eye & ENT Hospital, Fudan University, Shanghai, China.
Background:
The precise mechanisms by which alpha-lipoic acid (LA) alleviates nab-paclitaxel (nab-PTX)-induced peripheral neuropathy have yet to be fully elucidated. The objective of this study was to investigate the mechanisms underlying the neuroprotective effects of LA in mitigating nab-PTX-induced peripheral neuropathy.
Methods:
We established a rat model of nab-PTX-induced peripheral neuropathy to evaluate the efficacy of LA. To systematically elucidate the mechanisms by which LA alleviates nab-PTX-induced peripheral neuropathy, we utilized an integrated approach that combined network toxicology and network pharmacology. Subsequently, molecular docking analysis was performed to assess the binding affinity of the LA to the target proteins involved in the key signaling pathway. Furthermore, experimental validation was conducted to confirm the role of the key signaling pathway in the neuroprotective mechanism of LA.
Results:
LA was demonstrated to effectively alleviate nab-PTX-induced peripheral neuropathy. The network analysis indicated that LA ameliorated nab-PTX-induced peripheral neuropathy primarily through the AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, fluid shear stress and atherosclerosis, NOD-like receptor signaling pathway, and pathways of neurodegeneration - multiple diseases. The molecular docking indicated a potential impact of LA on the IL-17 signaling pathway. Further experiment validation revealed that nab-PTX activated the IL-17 signaling pathway, whereas LA could mitigate nab-PTX-induced peripheral neuropathy by inhibiting this pathway.
Conclusion:
By integrating network toxicology analysis, network pharmacology analysis, and experimental validation, this study provides a clearer understanding of the mechanisms by which LA ameliorates nab-PTX-induced peripheral neuropathy.
Insights
Alpha-lipoic acid (LA) effectively treats paclitaxel-induced neuropathy by inhibiting the IL-17 signaling pathway. This study clarifies LA's neuroprotective mechanisms against chemotherapy side effects.
Area of Science:
- Neuroscience
- Pharmacology
- Toxicology
Background:
- The exact mechanisms of alpha-lipoic acid (LA) in alleviating paclitaxel (nab-PTX)-induced peripheral neuropathy are not fully understood.
- Peripheral neuropathy is a significant side effect of nab-PTX chemotherapy, impacting patient quality of life.
Purpose of the Study:
- To investigate the underlying mechanisms of LA's neuroprotective effects against nab-PTX-induced peripheral neuropathy.
- To elucidate how LA mitigates chemotherapy-induced nerve damage.
Main Methods:
- Established a rat model of nab-PTX-induced peripheral neuropathy.
- Employed integrated network toxicology and network pharmacology approaches.
- Conducted molecular docking and experimental validation of key signaling pathways.
Main Results:
- LA demonstrated significant efficacy in alleviating nab-PTX-induced peripheral neuropathy.
- Network analysis identified key pathways including AGE-RAGE, IL-17, and neurodegeneration pathways.
- Experimental validation confirmed that LA inhibits the IL-17 signaling pathway, which is activated by nab-PTX.
Conclusions:
- This study elucidates the neuroprotective mechanisms of LA against nab-PTX-induced peripheral neuropathy.
- The findings highlight the critical role of the IL-17 signaling pathway in LA's therapeutic effect.
- Integrated network and experimental approaches provide a comprehensive understanding of LA's action.
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