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Beyond the blockade: unmet needs in systemic targeted atopic dermatitis therapy
Li Zhang1,2,3, Ge Peng3, Mingyue Wang1,2
1Department of Dermatology, The First Hospital of China Medical University, Liaoning, China.
Frontiers in Immunology
|December 15, 2025
Summary
New systemic therapies have improved atopic dermatitis treatment, but challenges remain in achieving lasting control and managing side effects. Future research aims for more effective, convenient treatments and better patient outcomes.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Atopic dermatitis (AD) management has advanced with systemic targeted therapies.
- These therapies modulate key inflammatory cytokine signaling pathways.
Purpose of the Study:
- To review current systemic targeted therapies for atopic dermatitis.
- To identify persistent unmet needs and outline future research directions.
Main Methods:
- Literature review of current atopic dermatitis treatments.
- Analysis of efficacy, limitations, and future therapeutic strategies.
Main Results:
- Janus kinase (JAK) inhibitors and interleukin-4/interleukin-13 (IL-4/IL-13) pathway inhibitors demonstrate significant efficacy.
- Unmet needs include stable disease control, managing nonresponders, side effects, and pruritus.
Conclusions:
- Despite advancements, challenges in atopic dermatitis treatment persist.
- Future directions focus on dual/multitarget drugs, improved formulations, novel targets, and patient-reported outcomes.
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