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Protein O-GlcNAcylation in Health and Diseases
Zhihong Ran1, Chuanbao Chen1, Jingfeng Ou1
1Department of Organ Transplantation The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.
O-GlcNAcylation, a protein modification, is vital for cell functions and homeostasis. Aberrant O-GlcNAcylation, however, drives diseases like cancer and neurodegeneration, presenting therapeutic targets.
Area of Science:
- Biochemistry
- Molecular Biology
- Cellular Biology
Background:
- O-GlcNAcylation is a dynamic posttranslational modification crucial for cellular processes.
- It regulates protein structure and function, impacting gene expression, cell cycle, metabolism, and signal transduction.
- Dysregulated O-GlcNAcylation is implicated in various pathologies, including neurodegenerative diseases, cancer, cardiovascular, and immune disorders.
Purpose of the Study:
- To systematically review the mechanisms of O-GlcNAcylation in physiological and pathological states.
- To evaluate the dual role of O-GlcNAcylation in maintaining homeostasis and promoting disease.
- To explore O-GlcNAcylation as a therapeutic target and discuss clinical applications.
Main Methods:
- Literature review and synthesis of existing research on O-GlcNAcylation.
- Analysis of the molecular mechanisms underlying O-GlcNAcylation in health and disease.
- Evaluation of therapeutic strategies and drug development related to O-GlcNAcylation.
Main Results:
- O-GlcNAcylation is essential for normal biological functions and organismal homeostasis.
- Aberrant O-GlcNAcylation significantly contributes to the pathogenesis of numerous diseases.
- The modification presents a promising target for therapeutic interventions.
Conclusions:
- O-GlcNAcylation plays a critical, dual role in health and disease.
- Targeting O-GlcNAcylation offers potential for novel therapeutic strategies.
- Further research is needed to overcome challenges in drug development for O-GlcNAcylation-related conditions.
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