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The predictive value of contrast-enhanced ultrasound parameters combined with inflammatory nutritional indicators for

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|December 15, 2025
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Summary

Contrast-enhanced ultrasound (CEUS) parameters combined with the Prognostic Inflammatory and Nutritional Index (PINI) can predict recurrence and survival in early-stage hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA). This CEUS-PINI system aids in personalized treatment strategies.

Keywords:
Contrast-enhanced ultrasoundhepatocellular carcinomainflammatory nutritional indexradiofrequency ablationrecurrence

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Area of Science:

  • Hepatobiliary Surgery
  • Medical Imaging
  • Oncology

Background:

  • Early-stage hepatocellular carcinoma (HCC) management often involves radiofrequency ablation (RFA).
  • Predicting recurrence and survival post-RFA is crucial for effective patient management.
  • Non-invasive methods are needed to assess prognosis in HCC patients undergoing RFA.

Purpose of the Study:

  • To evaluate the predictive value of contrast-enhanced ultrasound (CEUS) parameters and inflammatory-nutritional indices for HCC recurrence and survival after RFA.
  • To develop an evidence-based, personalized treatment strategy for early-stage HCC patients.
  • To assess the combined efficacy of CEUS parameters and the Prognostic Inflammatory and Nutritional Index (PINI) in predicting outcomes.

Main Methods:

  • Retrospective analysis of 263 early-stage HCC patients who underwent RFA.
  • Collection of CEUS data for tumor angiogenesis and hemodynamics.
  • Calculation of the Prognostic Inflammatory and Nutritional Index (PINI) and multivariate Cox analysis.

Main Results:

  • A low PINI score correlated with increased risk of recurrence and mortality post-RFA.
  • CEUS parameters (time to peak, peak intensity, enhancement rate) and PINI were significant predictors of recurrence and survival.
  • The combined CEUS-PINI scoring system effectively stratified patients into different risk groups for recurrence-free and overall survival.

Conclusions:

  • The combination of CEUS parameters and PINI offers a non-invasive prognostic tool for predicting recurrence and survival in early-stage HCC patients post-RFA.
  • The CEUS-PINI system assists in early identification of high-risk patients.
  • This approach supports the development of tailored postoperative monitoring and management strategies for HCC.