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Updated: Jun 26, 2026
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Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development
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Transcriptomic profiling of a canine malignant eyelid melanoma
Wallax Augusto Silva Ferreira1, Antonio Gomes Costa Neto de Sousa1, Thamirys Aline Silva Faro1
1Laboratory of Cytogenomics and Environmental Mutagenesis, Environment Section (SEAMB), Evandro Chagas Institute (IEC), Ananindeua, PA, Brazil.
Brazilian Journal of Veterinary Medicine
|December 15, 2025
Summary
Canine eyelid melanoma research is limited. This study reveals key molecular pathways and microRNAs involved in dog eyelid tumors, offering insights for veterinary and comparative oncology.
Area of Science:
- Veterinary Oncology
- Comparative Oncology
- Molecular Biology
Background:
- Malignant eyelid melanoma in dogs is aggressive and under-researched.
- Understanding its molecular basis is crucial for translational applications.
Purpose of the Study:
- To characterize the molecular landscape of canine eyelid melanoma.
- To identify potential diagnostic and therapeutic biomarkers.
Main Methods:
- Differential gene expression analysis.
- MicroRNA analysis.
- Comparative genomic analysis with human eyelid tumors.
Main Results:
- 1,437 significantly altered genes identified.
- Upregulated genes involved in immune response (chemokine signaling).
- Downregulated genes linked to cytoskeletal integrity and hormonal signaling.
- miR-134-5p and miR-146a-5p identified as potential oncogenic regulators.
Conclusions:
- Provides a comprehensive molecular profile of canine eyelid melanoma.
- Identifies key biomarkers and pathways for veterinary and comparative oncology.
- Highlights the utility of canine models for studying human eyelid cancers.
