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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Engaging Tertiary Benzylic Radicals in Metallaphotoredox Catalysis: A Modular Approach to Access Diaryl Quaternary
Samantha L Goldschmid1, Holly L Hutchinson1, Trevor C Sherwood2
1Department of Chemistry, Columbia University, New York, NY, 10027, USA.
None:
Herein we report the decarboxylative cross-coupling of tertiary benzylic carboxylic acids and aryl bromides to furnish all-carbon diaryl quaternary centers. For the first time, tertiary benzylic radicals are introduced as viable participants in metallaphotoredox-catalyzed cross-couplings by suppressing undesired benzylic radical dimerization via fast radical trapping with Cu. We demonstrate the functionalization of feedstock carboxylic acids as well as late-stage functionalization of carboxylic acid-containing drugs.
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