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Updated: May 2, 2026

Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
Carbazole-imidazole synergy for discriminative BSA sensing and a self-assembled organogel
Dharmendra Adak1, Sulekha Kumari Pandit1, Rajan Kumar2
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India. gdas@iitg.ac.in.
Abstract:
A newly designed imidazole-derived organogelator, CZDIM, demonstrates stimuli-responsive photophysical behaviour and shows high selectivity for detecting bovine serum albumin (BSA). The sensing capabilities of the probe, encompassing dynamic response, sensitivity, and selectivity, have been meticulously examined. Furthermore, the sensing mechanism was elucidated through displacement experiments, synchronous spectroscopy, circular dichroism, time-resolved photoluminescence, and molecular docking. The unique effective response to BSA originated from the hydrophobic and electrostatic interactions of the probe via a site-specific interaction at Site II. This study may offer a straightforward method for constructing new probes for BSA with enhanced selectivity.
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