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Updated: Oct 21, 2026

In vivo 19F MRI for Cell Tracking
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Correction to "Intracellular Binding of Novel Fluorinated Compounds to Carbonic Anhydrase Isoforms Explored by

Azzurra Costantino1, Letizia Barbieri1,2, Simone Giovannuzzi3

  • 1CERM - Magnetic Resonance Center, University of Florence, via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy.

Journal of Medicinal Chemistry
|December 15, 2025
PubMed
Abstract

No abstract available in PubMed .

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In an NMR sample, precise measurement of the absolute absorption frequencies of nuclei is difficult. A standard internal reference compound is added, and the frequency difference between the reference signal and sample signals is measured.
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...