Sustainable Minisci-Type Acylation of N-Heteroarenes via HAT Using Chlorine Radicals Generated by LMCT Excitation
Mingyang Wan1, Jiatian Zhuo1, Yuchen Pan1
1School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, China.
Abstract:
An efficient and sustainable Minisci-type C(sp2)-C(sp2) cross-coupling of N-heteroarenes with aldehydes has been developed. The reaction employs FeCl3 as photocatalyst, purple LED light as the energy source, and air as the sole oxidant, operating smoothly at ambient temperate. This protocol shows broad substrate scope and good functional group tolerance. Mechanistic studies reveal that LMCT-generated chlorine radicals mediate acyl radical generation, providing a cost-effective, atom-economical, and green approach to acylated azaheterocycles.
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