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Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
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CSI and Musculoskeletal Pain: Clinical Validity and Neurophysiological Implications.

Anna Anselmo1, Maria Pagano1, Irene Cappadona2

  • 1IRCCS Centro Neurolesi Bonino-Pulejo, Via Palermo, SS 113, C. da Casazza, Messina, 98124, Italia.

Current Pain and Headache Reports
|December 15, 2025
PubMed
Summary

The Central Sensitization Inventory (CSI) effectively screens for chronic pain, but combining it with objective measures like laser-evoked potentials (LEPs) offers a more precise diagnosis and personalized treatment approach.

Keywords:
Central sensitizationCentral sensitization inventoryLaser-Evoked potentialsMusculoskeletal pain

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Area of Science:

  • Pain Medicine
  • Neuroscience
  • Clinical Assessment

Background:

  • Chronic pain impacts 20% of adults globally, significantly reducing quality of life.
  • Shared symptoms like fatigue, poor sleep, anxiety, and depression suggest a common mechanism, possibly central sensitization.
  • Central sensitization, a nervous system's amplified pain response, is a key factor in chronic pain syndromes.

Purpose of the Study:

  • To evaluate the validity of the Central Sensitization Inventory (CSI) for assessing central sensitization in chronic musculoskeletal pain.
  • To explore the integration of objective measures, such as laser-evoked potentials (LEPs), with subjective tools for enhanced diagnosis.
  • To improve diagnosis and guide targeted treatment strategies for chronic pain.

Main Methods:

  • A systematic review following PRISMA guidelines was performed.
  • Searches were conducted across major databases (PubMed, Web of Science, Scopus, etc.) for studies published before September 2025.
  • Included studies were screened for eligibility, and their quality was assessed using JBI checklists.

Main Results:

  • Eight studies met the inclusion criteria, all utilizing the CSI.
  • The CSI demonstrated validity and practicality, correlating with pain, disability, and reduced quality of life.
  • Limitations of the CSI's subjective nature were acknowledged.

Conclusions:

  • The Central Sensitization Inventory (CSI) is a valuable tool for initial chronic pain screening.
  • Combining the CSI with objective measures like laser-evoked potentials (LEPs) enhances diagnostic precision.
  • Integrated assessment improves chronic pain management and treatment personalization.