Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.7K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computer Vision for Predicting the Efficacy of Neoadjuvant Therapy in Breast Cancer.

Cancers·2026
Same author

SPHERpower: MSC spheroid-based bioequivalent lead to the efficient restoration of the scarred vocal folds.

Stem cell research & therapy·2026
Same author

Sex-Stratified Machine Learning for the Prediction of Post-COVID Condition: A Longitudinal Cohort Study.

Journal of clinical medicine·2026
Same author

Correction: Mitochondrial-mediated apoptosis as a therapeutic target for FNC (2'-deoxy-2'-b-fluoro-4'-azidocytidine)-induced inhibition of Dalton's lymphoma growth and proliferation.

Discover oncology·2026
Same author

Comparison of Fascicular Turnover Flap and Autograft in a Rat Facial Nerve Model.

Journal of clinical medicine·2026
Same author

Liver-on-a-Chip: Searching for a Balance Between Biomimetics and Functionality.

Biosensors·2026

Related Experiment Video

Updated: Jan 8, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

12.9K

Targeting autophagy and metabolism for ewing sarcoma.

Kamilla Antoshina1, Denis Aniskin1, Mikhail Stempen1

  • 1Laboratory for Molecular and Cellular Tumor Therapy, Institute for Regenerative medicine n,, I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia.

Molecular Biology Reports
|December 15, 2025
PubMed
Summary

Ewing sarcoma, a deadly cancer in young people, has high recurrence rates. Targeting autophagy and metabolism together may offer new treatment strategies for this aggressive bone and soft tissue tumor.

Keywords:
AutophagyCellular signallingMetabolismSarcomaTumor resistance

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.2K
Quantitative Analysis of Autophagy using Advanced 3D Fluorescence Microscopy
09:59

Quantitative Analysis of Autophagy using Advanced 3D Fluorescence Microscopy

Published on: May 3, 2013

18.4K

Related Experiment Videos

Last Updated: Jan 8, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

12.9K
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.2K
Quantitative Analysis of Autophagy using Advanced 3D Fluorescence Microscopy
09:59

Quantitative Analysis of Autophagy using Advanced 3D Fluorescence Microscopy

Published on: May 3, 2013

18.4K

Area of Science:

  • Oncology
  • Cell Biology

Background:

  • Ewing sarcoma is an aggressive bone and soft tissue cancer affecting young individuals.
  • Despite improved survival rates, high recurrence rates persist, highlighting treatment challenges.

Purpose of the Study:

  • To review the dual role of autophagy in cancer, acting as both a tumor promoter and suppressor.
  • To explore the significance of metabolic pathways, including amino acids, glucose, and lipids, in Ewing sarcoma development.
  • To investigate combined therapeutic strategies targeting both autophagy and metabolism in Ewing sarcoma treatment.

Main Methods:

  • Literature review of studies on autophagy and metabolism in Ewing sarcoma.
  • Analysis of the dual role of autophagy (cytoprotective vs. cytotoxic).
  • Examination of metabolic reprogramming in cancer cells.

Main Results:

  • Autophagy's complex role in cancer necessitates caution when considering it as a therapeutic target.
  • Metabolic pathways are significantly altered in proliferating cancer cells.
  • Current understanding of autophagy and metabolism in Ewing sarcoma treatment remains incomplete.

Conclusions:

  • Targeting both autophagy and metabolism simultaneously presents a promising avenue for novel Ewing sarcoma therapies.
  • Further research is needed to elucidate the precise functions and outcomes of combined targeting strategies.
  • Developing effective treatments requires a deeper understanding of the interplay between autophagy and metabolism in Ewing sarcoma.