Anal Phyllodes Tumor in a Man: An Exceptionally Rare Case Report and Literature Review

Phyllodes tumors are fibroepithelial neoplasms most commonly found in the breast, and their occurrence in the anogenital region-especially in male patients-is exceedingly rare. We describe a man who presented with a localized mass in the anal region. The lesion was excised, and gross examination revealed the characteristic leaf-like clefts typical of phyllodes tumors. Histopathological analysis demonstrated a biphasic morphology, composed of epithelial and stromal components. Immunohistochemical staining showed positivity for estrogen receptor, GATA3, and mammaglobin in the epithelial component, while the stromal component was positive for CD34. This rare tumor highlights that phyllodes tumors can occur in the anogenital region of men and emphasizes the importance of distinguishing them from other anal tumors. Long-term follow-up is recommended after resection.