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Updated: Jan 8, 2026
05:01
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
Published on: July 1, 2020
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AKR1B1 bridges metabolic pathways and disease progression
Qinyu Zhang1, Zhe Cao2, Tao Wang3
1Science and Technology Innovation Center, Hunan University of Chinese Medicine, Changsha 410208, China.
Cellular Signalling
|December 15, 2025
Summary
Aldo-keto reductase 1B1 (AKR1B1) impacts metabolism and disease. This review explores AKR1B1
Area of Science:
- Biochemistry
- Metabolic pathways
- Enzyme function
Background:
- Aldo-keto reductase 1B1 (AKR1B1) is a crucial oxidoreductase.
- AKR1B1's role in disease pathogenesis is not fully understood.
- Existing literature on AKR1B1 is fragmented.
Purpose of the Study:
- To review AKR1B1's metabolic functions in health and disease.
- To discuss AKR1B1's pathological involvement in various disorders.
- To summarize clinical research on AKR1B1 inhibitors.
Main Methods:
- Literature review of AKR1B1's physiological roles.
- Analysis of AKR1B1's involvement in diabetic complications, inflammation, and cancer.
- Review of clinical trial data for AKR1B1 inhibitors.
Main Results:
- AKR1B1 is integral to multiple metabolic pathways.
- AKR1B1 contributes to diabetic complications, inflammatory diseases, and cancer.
- AKR1B1 inhibitor research shows progress but faces challenges.
Conclusions:
- Integrating metabolic and disease insights is key to understanding AKR1B1.
- Further research is needed to advance AKR1B1 knowledge.
- AKR1B1 presents a potential therapeutic target.
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