Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

915
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
915
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

614
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
614
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

859
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
859
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

732
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
732
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

445
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
445
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

424
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
424

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neonatal arterial thrombosis: an arcane COVID sequelae.

BMJ case reports·2024
Same author

Paradoxical immune reconstitution inflammatory syndrome in neurotuberculosis.

BMJ case reports·2021
Same author

Double trouble: a pandemic of obesity and COVID-19.

The lancet. Gastroenterology & hepatology·2021
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

4.4K

Stroke in paediatric Crohn's disease.

Sai Anjali Kambala1, Seema Pavaman Sindgikar2, Daniya Hameed1

  • 1Paediatrics, Nitte (Deemed to be University), KS Hegde Medical Academy (KSHEMA), Mangalore, Karntaka, India.

BMJ Case Reports
|December 15, 2025
PubMed
Summary

This case study highlights a rare neurological complication in Crohn's disease (CD). Prompt treatment with infliximab led to remission of CD and recovery from stroke-related deficits.

Keywords:
Crohn's diseaseGastrointestinal systemStroke

More Related Videos

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.4K
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

11.0K

Related Experiment Videos

Last Updated: Jan 8, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

4.4K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.4K
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

11.0K

Area of Science:

  • Neurology
  • Gastroenterology
  • Immunology

Background:

  • Neurological complications in inflammatory bowel disease (IBD) are uncommon but significantly increase patient morbidity.
  • Poorly controlled IBD, characterized by recurrent disease flares, elevates the risk of neurological sequelae.
  • Crohn's disease (CD) management can be challenging, particularly in adolescents with treatment-resistant disease.

Purpose of the Study:

  • To present a case of a rare neurological complication, specifically a stroke, in an adolescent with difficult-to-treat Crohn's disease.
  • To illustrate the diagnostic and therapeutic challenges in managing such complex cases.
  • To emphasize the importance of timely and appropriate treatment for both the underlying IBD and its neurological complications.

Main Methods:

  • A detailed case report of an adolescent female diagnosed with Crohn's disease.
  • Review of her clinical history, including recurrent gastrointestinal symptoms and previous treatment attempts.
  • Neuroimaging (including angiography) to evaluate the stroke and associated venous sinus thrombosis.
  • Initiation of emergency stabilization with antiepileptics and anticoagulants, followed by infliximab therapy during rehabilitation.

Main Results:

  • The patient experienced a haemorrhagic stroke with infarction, superior sagittal sinus thrombosis, and left transverse sinus thrombosis during a Crohn's disease flare-up.
  • Despite initial financial constraints preventing biological therapy, the patient was eventually treated with infliximab.
  • Following treatment, the patient achieved partial remission of Crohn's disease, with complete recovery of facial and limb neurological deficits.

Conclusions:

  • This case underscores the potential for severe neurological complications, such as stroke, in patients with inflammatory bowel disease, particularly during disease flares.
  • Effective management of the underlying inflammatory bowel disease, including the use of biological agents like infliximab, is crucial for preventing and treating these complications.
  • Early diagnosis and multidisciplinary management are essential for improving outcomes in IBD patients with neurological involvement.