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Reprogramming heart failure: physiological orchestration and mechanistic decoding of exercise benefits.
Longfei Xu1, Congfei Chen1,2, Kun Wang3
1Military Medical Sciences Academy, 1 Dali Road, Heping District, Tianjin, 300050, China.
BMC Cardiovascular Disorders
|December 15, 2025
Summary
Physical exercise offers a promising non-invasive approach to manage heart failure (HF). This review explores how exercise impacts key mechanisms like mitochondrial function and angiogenesis in HF patients.
Area of Science:
- Cardiology
- Exercise Physiology
- Molecular Biology
Background:
- Heart failure (HF) is a complex syndrome resulting from cardiac damage, leading to reduced pumping ability.
- HF pathophysiology involves complex molecular and cellular mechanisms that sustain physiological functions.
- Current HF treatments aim to manage compensatory mechanisms, but improved quality of life remains a goal.
Purpose of the Study:
- To review the mechanisms by which physical exercise modulates heart failure.
- To consolidate current understanding of exercise's effects on HF.
- To encourage further research into exercise-based HF management.
Main Methods:
- Literature review focusing on exercise interventions in heart failure.
- Analysis of studies examining exercise's impact on myocardial mitochondrial bioenergetics.
- Examination of research on exercise, angiogenesis, cardiogenic dementia, and microRNAs in HF.
Main Results:
- Exercise modulates myocardial mitochondrial bioenergetics.
- Physical activity influences angiogenesis and may impact cardiogenic dementia.
- Exercise affects microRNA profiles relevant to heart failure.
Conclusions:
- Non-invasive therapeutic options like physical exercise present new avenues for HF management.
- Optimized exercise protocols are crucial for understanding exercise's role in HF.
- Further research is needed to fully elucidate the benefits of exercise in HF.
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